By using the Liquisolid technique, sustained drug delivery systems were developed for the water soluble drugs in which hydrophobic non-volatile solvents are. Abstract. Liquisolid technique is also known as powder solution technology. It is the technique which deals with the solubility enhancement of poorly soluble. Acta Pharm. Mar;57(1) Liquisolid technique as a tool for enhancement of poorly water-soluble drugs and evaluation of their physicochemical.
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Liquisolid preparations may be hampered by their poor and erratic flow and compaction properties. Then, the coating material having techniwue adsorptive properties and large specific surface area gives the liquisolid system the desirable flow characteristics. Segatto Silvac, Hellen K. At near critical temperature, SCFs are highly compressible allowing moderate changes in pressure to greatly alter the density and mass transport characteristics of a fluid that determines its solvent tecnique.
The accurately weighed physical mixtures of liquisolid compacts were taken in a funnel.
Pharmaceutical applications of liquisolid technique
In this method, a fixed height loquisolid method procedure was performed in triplicate and average angle of repose calculated Rania et al. In this technique, the drug might be in solid dosage form and dissolved in solution or a solvent. The following parameters describe a measure of the flow properties of liquisolid systems that will be selected and compressed into tablets.
Liquisolid systems pre compression and drug release properties increase with powder excipient ratios R from 5: Techinque Center for Biotechnology InformationU. Therefore, a big challenge for dissolution and bioavailability enhancement of these drugs had developed. This liquid medication is poured on the suitable amount of carrier material. It is one of the novel techniques which is used for solubility enhancement and bioavailability of poorly water soluble drug.
It should be compatible with having ability to solubilise the drug. Bioavailability of many class II and class IV drugs get enhanced by using liquisolid technique. This method is efficient, economic, viable for industrial production, also useful in control drug delivery system.
It is the technique which deals with the solubility enhancement of poorly soluble drugs. Exhibits enhanced in-vitro drug release as compared to commercial counterparts, including soft gelatin capsule preparations.
The liquid solvent is removed by evaporation under reduced pressure or by freeze drying which result in amorphous precipitation of guest in a crystalline carrier.
Several methods are studied for increasing dissolution performance and bioavailability including micronization, Nanonisation, complexation with cyclodextrins, solid dispersion, self emulsifying system, liquisolid systems etc. The graduated cylinder was then allow to tap at constant velocity until a constant volume is obtained, when the powder was considered to have reached the most stable arrangement, the final bulk volume was recorded. When drug dissolved in liquid carrier is poured onto a porous carrier material, liquid gets absorbed in its internal structure, and after saturation, adsorption on external surface occurs.
Processing factors in development of solid solution formulation of itraconazole for enhancement of drug dissolution behavior of water insoluble drugs.
The liquid medication is absorbed into the carrier material internally and externally and then a suitable disintegrant was added to this material. In-vivo evaluation of hydrochlorothiazide liquisolid tablet in beagles dogs. Downloads Download data is not yet available.
The absorbate molecules diffuse inside the absorbent and are eventually captured by the powder particles within their bulk, and thus absorption of the liquid occurs. Mechanism of enhancement of solubility: The liquisolid approach is a promising technology because of the simple manufacturing process, low production costs and the possibility of industrial manufacture due to the good flow and compaction properties of liquisolid formulation. This will increase the weight of tablets to above one gram which makes them difficult to swallow.
This free flowing powder is than subjected to Preformulation studies like Fourier transformed infrared spectroscopy, differential scanning Calorimetry for compatibility studiesangle of slide, flow properties, solubility studies, calculation of liquid load retention potential, liquid load factor etc.
The Liquisolid technique: an overview
Liquisolid systems based on the type of liquid medication can be classified into three sub groups: The non volatile solvents used in the liquisolid system mainly acts as binding agent. Here, agglomeration of the drug particles is prevented due to the binding of drug tedhnique the carrier. However, the formulation of soft gelatin capsules is expensive and requires sophisticated technology.
Finally, this study reported that MCC PH is a suitable carrier for preparing liquisolid systems in terms of having acceptable flowability, friability, hardness, and dissolution profile. Aging had no effect on hardness or dissolution profile of liquisolid tablets prepared from MCC PH Non-volatile solvent present in the liquisolid system facilitates wetting of drug particles by decreasing interfacial tension between dissolution medium and tablet surface.
This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4. Thus, due to substantial increase in wettability and effective surface area for dissolution, liquisolid compacts may be expected to reveal enhanced release profiles of water-insoluble drugs. Micronization is the most common method used to increase the surface area of the drug, but this becomes less effective when they are formulated as tablets or encapsulations Aguiar et al.
By using the Liquisolid technique, sustained drug delivery systems were developed for the water soluble drugs in which hydrophobic non-volatile solvents are used as vehicles. There are several approaches for solubility enhancement which includes micronization, Nanonisation, use of salt forms, use of surfactant, solid dispersion, and supercritical fluid recrystalization etc.
Therefore, this is due to their significantly increased wetting properties and increased surface area of drug available for dissolution.
During this continuous mixing in the mortar should be going on. Due to their significantly improved wetting liquisoid a greater drug surface area is exposed to the dissolution media, resulting in an increased dissolution rate and bio availability. Moreover, this technique has been explored as an instrument to reduce the pH variation effect on drug release.
Powdered liquid drug Powdered drug solutions.
With this technology liquids such as solutions or suspensions of poorly soluble drugs in a non-volatile liquid vehicle are converted into acceptably flowing and compressible powders by simple liquisolkd blending with selected excipients named the carrier and the coating material.