Controlled release matrix tablets with HPMC KLV, HPMC K4M, HPMC K15M, and HPMC KM were formulated by wet (non-aqueous) granulation method. Surface plots of log viscosity with temperature (°C) and HPMC concentration (%, w/w) for HPMC a K LV, b K4M, c K15M and d KM. Download/Embed scientific diagram | Swelling index of HPMC K4M at different concentrations from publication: Influence of different grades and concentrations .
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On the other hand, an increase in temperature increased the kinetic energy of the molecules, resulting in greater molecular mobility and reduction in viscosity. That is, when the solution heats up to a critical temperaturethe solution congeals into a non-flowable but semi-flexible mass.
J Colloid Interface Sci. Gpmc Wah Chan, Phone: Formulation of kk4m release promethazine hydrochloride tablets using hydroxypropyl methylcellulose matrices. In the present study, the influence of ten different grades of HPMC at various concentrations on the viscosity of PEG melt suspension at different temperatures was evaluated using surface plots.
It was, however, reported that the change in the polymer disentanglement concentration between KLV and other viscosity grades was appreciable leading to a higher release rates for the KLV matrices. Polymer rheology plays a crucial role in polymer processing and polymer manufacturing.
Multivariate methods in pharmaceutical applications. Group 1 represented the formulations whose viscosities were the highest and group 4 the lowest.
Controlled Release Hydrophilic Matrix Tablet Formulations of Isoniazid: Design and In Vitro Studies
HPMC-matrices for controlled drug delivery: The rheological data obtained was then converted to surface plots using the graphical software DPlot V2. Although polymers have been studied over phmc years, polymer rheology is a difficult subject to comprehend 1. The point of deflection was postulated to coincide with maximum disentanglement of all the polymer chains of PEG.
Pharmacology of some slow-release preparations of isoniazid of potential use in intermittent treatment of tuberculosis. Multivariate parameter evaluation of pharmaceutically important cellulose ethers.
The following variations in tablet formulae were done and their effect on in vitro release rate, release mechanism Fickian or non-Fickianand nature of release order of release was studied.
The authors declare no conflict of interest. However, no literature was found on the use of HPMC polymer as a tablet matrix forming material for the development of controlled release formulations of isoniazid. The melt dispersion could be more efficiently conveyed or atomised if its viscosity is not excessively high. Granule and tablet formulae study by principal component analysis.
Preparation of micropellets by spray congealing. The increased K deg values found at higher humidity condition supported the fact that avoidance of aqueous granulation technology use of IPA granulation in the manufacturing of isoniazid matrix tablets was significantly beneficial in obtaining the stable CR matrix tablets of isoniazid.
In Vitro Release Studies Plots of percent cumulative drug released vs. Formulation of biphasic release tablets containing slightly soluble drugs. Formulations in the low viscosity clusters 0. The aim of the present investigation was to develop oral controlled release matrix tablet formulations of isoniazid using hydroxypropyl methylcellulose HPMC as a hydrophilic release retardant polymer and to study the influence of various formulation factors like proportion of the polymer, polymer viscosity grade, compression force, and release media on the in vitro release characteristics of the drug.
However, a detailed comparison of the viscosities at each and every temperature and concentration between the various grades of adjuvants in the formulation will be tedious and time-consuming.
Detailed comparison of the viscosities at each and every temperature and concentration between the various grades of HPMC was very tedious and time-consuming. H;mc special grade of Methocel VLV, developed for coating purposes, was also included in this jpmc.
The viscosity profiles suggested that the F-series generally had more extensive particle-particle interactions compared to the K-series, followed by the E-series hpmmc the same concentration. Hypromellose in an aqueous solution, unlike methylcelluloseexhibits a thermal gelation property.
The rheological properties of polymer melts in these processes, if uncontrolled, may lead to a blockage or high backpressure in the extrusion system, clogging of the spray delivery system or inadequate filling of melts into moulds, which often necessitate the termination of the process. It cannot be assumed that the viscosity trends will remain consistent when more components are added to the formulation. This phenomenon resulted in the decreased effective diffusion of the drug and therefore a reduction in k4mm drug release rate.
As a food additivehypromellose is an emulsifierthickening k4n suspending agent, and an alternative to animal gelatin. On the other hand, increase in particle size reduced the number of particles for the same HPMC concentration and reduced retardation of flow.
From the in vitro studies, the formulations were found to be promising and could further be considered for in vivo bioavailability studies in suitable animal models or human volunteers to assess in vivo performance and bioavailability. William Andrew Publishing;