FOSCARNET PRESCRIBING INFORMATION PDF

Mar 18 2020
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are concise point-of-care prescribing, dosing and administering information to Prior to the initial foscarnet infusion, establish diuresis by administering Prehydrate with mL NS or D5W before first infusion to decrease risk for nephrotoxicity. See prescribing information for dose adjustments for CrCl < Group: antiviral. Solution for injection, 24 mg/ml ml, ml [non-EDL]. General information. Foscarnet is a non-nucleoside pyrophosphate analogue given.

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In addition, TdP has been reported with postmarketing use of solifenacin, although causality was not determined.

Arotinolol Foscarnet may decrease the excretion rate of Arotinolol which could result in a higher serum level. Buprenorphine has also been associated with QT prolongation prescribinb has a possible risk of TdP.

Due to the extremely long half-life of amiodarone, a drug interaction is possible for days to weeks after discontinuation of amiodarone. Foscarnet exerts its antiviral activity by a selective inhibition at the pyrophosphate binding site on virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases.

Givinostat The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Givinostat. Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide: Ketoconazole The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Ketoconazole. Phylloquinone Foscarnet may decrease the excretion rate of Phylloquinone which could result in a higher serum level.

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Robenacoxib The risk or severity of nephrotoxicity can be increased when Robenacoxib is combined with Foscarnet. Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate: Acrivastine Foscarnet may decrease the excretion rate of Acrivastine which could result in a higher serum level. Major When possible, avoid concurrent use of foscarnet with other drugs known to prolong the QT interval, such as ondansetron.

Stavudine The excretion of Stavudine can be decreased when combined with Foscarnet. Major Systemic polymyxin B should not be used concurrently or sequentially with other drugs that have the potential for nephrotoxicity or neurotoxicity such as foscarnet. Men treated with Incormation should not father a child during or up to 6 months after therapy. Major When possible, avoid concurrent use of foscarnet with other drugs known to prolong the QT interval, such as telavancin.

Dacarbazine Foscarnet may decrease the excretion rate of Dacarbazine which could result in a higher serum level.

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Mutagenicity studies showed that foscarnet has a genotoxic potential. Infection recurred in most patients a median of 14 days after foscarnet therapy was discontinued.

TdP and sudden death have also been reported in patients receiving vandetanib. Cefodizime Doscarnet risk or severity of nephrotoxicity can be increased when Cefodizime is combined with Foscarnet. Lisinopril Foscarnet may decrease the excretion rate of Lisinopril which could result in a higher serum level.

Magnesium chloride Foscarnet may decrease the excretion rate of Magnesium chloride which could result in a higher serum level.

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WHO Model Prescribing Information: Drugs Used in HIV-Related Infections: Drugs: Foscarnet

Minor Due to the inhibition of renal prostaglandins by salicylates, concurrent use of salicylates and other nephrotoxic agents, such as foscarnet, may lead presctibing additive nephrotoxicity.

Formoterol The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Formoterol.

Fingolimod The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Fingolimod. Mibefradil The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Mibefradil.

Androgen deprivation therapy e. Fertility There are no data available regarding the influence of Foscavir on fertility. Hydroxyzine The risk or severity of QTc prolongation can be increased when Foscarnet is combined fosarnet Hydroxyzine.

Foscarnet Injection: MedlinePlus Drug Information

Piroxicam The risk or severity of nephrotoxicity can be increased when Piroxicam is combined with Foscarnet. This reduction may also have a rpescribing on heart function e. Talk to your doctor about the risks of using this medication for your condition. QT prolongation and TdP have also been observed during haloperidol treatment.

Foscavir is not recommended in patients undergoing haemodialysis since dosage guidelines have not been established.